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    會員登錄 - 用戶注冊 - 設為首頁 - 加入收藏 - 網站地圖 選擇生物標志物的基本原則 生物醫學上的標志物,給個定義?!

    選擇生物標志物的基本原則 生物醫學上的標志物,給個定義?

    時間:2021-10-22 07:45:43 來源:電加熱器 江蘇電加熱器 鹽城市鋒嘉電熱電器制造有限公司,專業生產電加熱器 作者:德州市 閱讀:635次
    生物醫學上的標志物,給個定義?生物標志物(Biomarker)是指可以標記系統、器官、組織、細胞及亞細胞結構或功能的改變或可能發生的改變的生化指標,具有非常廣泛的用途。生物標志物可用于疾病診斷、判斷疾病分期或者用來評價新藥或新療法在目標人群中的安全性及有效性。對于疾病研究,生物標志物一般是指可供客觀測定和評價的一個普通生理或病理或治療過程中的某種特征性的生化指標,通過對它的測定可以獲知機體當前所處的生物學過程中的進程。 檢查一種疾病特異性的生物標志物,對于疾病的鑒定、早期診斷及預防、治療過程中的監控可能起到幫助作用。尋找和發現有價值的生物標志物已經成為目前研究的一個重要熱點。自1994年蛋白質組概念提出,定量蛋白質組學已經成為蛋白質組學研究的熱點和中心。定量蛋白質組學便是檢測正常與疾病狀態下組織全部表達蛋白質在量上的差別。定量蛋白質組學中的蛋白質定量技術也成為發現生物標志物的重要途徑。生物標志物是生物體受到嚴重損害之前,在不同生物學水平(分子、細胞、個體等)上因受環境污染物影響而異?;男盘栔笜?。它可以對嚴重毒性傷害提供早期警報。這種信號指標可以是細胞分子結構和功能的變化、可以是某一生化代謝過程的變化或生成異常的代謝產物或其含量,可以是某一生理活動或某一生理活性物質的異常表現,可以是個體表現出的異?,F象,可以是種群或群落的異常變化,可以是生態系統的異常變化。選擇原則1.所選擇的生物標志物必須具有一定的特異性。2.所選擇的生物標志物必須具有足夠的靈敏度,即所選標志物的水平與外接觸水平要有劑量一反應關系,在無害效應接觸水平下仍能維持這種關系。3.所選擇的生物標志物分析的重復性及個體差異都在可接受的范圍內。4.所選擇的生物標物要有足夠的穩定性,便于樣品的運送、保存、分析。5.取樣時最好對人體無損生,能為受試者所接受。

    (責任編輯:邯鄲市)

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    14学生粉嫩下面自慰照片

    <optgroup id="yoilo"></optgroup>

      <span id="yoilo"><output id="yoilo"><nav id="yoilo"></nav></output></span> <legend id="yoilo"><li id="yoilo"></li></legend>

      <span id="yoilo"><output id="yoilo"><nav id="yoilo"></nav></output></span>
      <optgroup id="yoilo"><li id="yoilo"><source id="yoilo"></source></li></optgroup>
      <track id="yoilo"><i id="yoilo"></i></track>
    1. <acronym id="yoilo"></acronym>
      <optgroup id="yoilo"><li id="yoilo"><source id="yoilo"></source></li></optgroup>